Copyright Statement

Thesis Title: Nuclear Organization and Myt1 Interaction in Transcriptional Control of Neural Cell Differentiation Name: Joseph Allen Nielsen Molecular and Cell Biology Uniformed Services University of the Health Sciences Ph.D. candidate 2002 Thesis directed by: Regina Armstrong, Ph.D. Department of Anatomy, Physiology and Genetics Uniformed Services University of the Health Sciences Neural cell differentiation is a complex set of events beginning with cells responding to both soluble and cell contact-dependent external signals. These signals activate pathways that lead to changes in gene expression patterns, which ultimately give rise to the differentiated cell phenotype. In these studies, potential mechanisms regulating different aspects of oligodendrocyte differentiation were explored. Specifically, these studies examined the contribution of gene and protein localization to the establishment and/or maintenance of terminally differentiated oligodendrocyte gene expression